Amylyx Pharmaceuticals, Inc. (AMLX) vs TransMedics Group, Inc. (TMDX)

A side-by-side comparison of Amylyx Pharmaceuticals, Inc. and TransMedics Group, Inc. across valuation, profitability, dividends, and growth — built entirely from reported fundamentals, as of October 6, 2026. Differences are shown without an overall score or investment verdict.

Compare
Amylyx Pharmaceuticals, Inc. logo
AMLX
Amylyx Pharmaceuticals, Inc.
$3.02B
$27.17HealthcareDelayed quote: Oct 6, 2026, 10:40 AM EDT
TransMedics Group, Inc. logo
TMDX
TransMedics Group, Inc.
$2.79B
$80.68HealthcareDelayed quote: Oct 6, 2026, 10:40 AM EDT

Total return — AMLX vs TMDX

growth of $100 · dividends reinvested · last 5y
AMLX +53.7% (+9.0%/yr)TMDX +377.5% (+36.7%/yr)TMDX compounded faster over this window
02004006008001kStart $1002023202420252026$154$478
AMLX TMDX

AMLX vs TMDX: by the numbers

  • •AMLX is the larger company ($3.02B vs $2.79B market cap).
  • •TMDX is profitable (22.69% net margin) while AMLX runs a net loss (0.00%).

Metrics side by side

Valuation

MetricAMLXTMDX
P/E ratioN/A20.90
Forward P/EN/A55.00
P/S ratioN/A4.17
P/B ratio12.635.38
EV / EBITDAN/A26.97
FCF yieldN/A2.83%

Profitability

MetricAMLXTMDX
Gross margin0.00%58.69%
Operating margin0.00%12.21%
Net margin0.00%22.69%
ROE-63.59%29.28%
ROIC-66.60%5.87%

Growth (annualized)

MetricAMLXTMDX
Revenue CAGR (5Y)N/A86.12%
Total return CAGR (5Y)N/A21.77%

Frequently asked

Is AMLX or TMDX more profitable?
TMDX runs the higher net margin — AMLX at 0.00% versus TMDX at 22.69%.

Go deeper

Full AMLX analysisFull TMDX analysisInteractive comparison tool

Dig into the metrics

TransMedics P/E ratioAmylyx Pharmaceuticals ROETransMedics ROEAmylyx Pharmaceuticals operating marginTransMedics operating marginAmylyx Pharmaceuticals revenue growthTransMedics revenue growthAmylyx Pharmaceuticals free cash flowTransMedics free cash flow

Amylyx Pharmaceuticals & TransMedics appear in these rankings

Fastest Revenue Growth StocksHighest ROE Stocks

Figures are sourced from reported fundamentals and the latest end-of-day price. This comparison is informational only and is not investment advice. Past performance does not predict future results. See our methodology. Compiled by TGMCharts Research · data verified October 6, 2026.