Which has the lower trailing P/E, AMGN or ISRG?

AMGN has the lower trailing P/E: AMGN trades at 25.05 and ISRG at 44.59. P/E is one valuation measure and does not by itself establish which business is cheaper.

Which has grown faster, AMGN or ISRG?

Over the past five years, ISRG grew revenue faster — AMGN at a 8.39% CAGR versus ISRG at 16.41%.

Does AMGN or ISRG pay a bigger dividend?

AMGN pays a dividend (2.47% yield), while ISRG has no payments in the available dividend history.

Is AMGN or ISRG more profitable?

ISRG runs the higher net margin — AMGN at 22.93% versus ISRG at 28.45%.

How have AMGN and ISRG total returns compared?

Over the past 10 years, AMGN delivered 12.52% and ISRG delivered 17.14% annualized total return. Past performance doesn't predict future results.

Amgen Inc. (AMGN) vs Intuitive Surgical, Inc. (ISRG)

A side-by-side comparison of Amgen Inc. and Intuitive Surgical, Inc. across valuation, profitability, dividends, and growth — built entirely from reported fundamentals, as of October 4, 2026. Differences are shown without an overall score or investment verdict.

AMGN

Amgen Inc.

$217.52B

$403.04HealthcareDelayed quote: Oct 2, 2026, 4:00 PM EDT

ISRG

Intuitive Surgical, Inc.

$138.47B

$391.95HealthcareDelayed quote: Oct 2, 2026, 4:00 PM EDT

Total return — AMGN vs ISRG

growth of $100 · dividends reinvested · last 10y

AMGN +228.1% (+12.6%/yr)ISRG +392.5% (+17.3%/yr)ISRG compounded faster over this window

AMGN ISRG

AMGN vs ISRG: by the numbers

•AMGN is the larger company ($217.52B vs $138.47B market cap).
•AMGN trades at the lower trailing earnings multiple (25.05 vs 44.59 P/E), one valuation lens rather than an overall verdict.
•ISRG converts more revenue to profit (28.45% vs 22.93% net margin).
•ISRG grew revenue faster over the past five years (16.41% vs 8.39% CAGR).
•AMGN pays a dividend (2.47% yield), while ISRG has no payments in the available dividend history.

Metrics side by side

Valuation

Metric	AMGN	ISRG
P/E ratio	25.05	44.59
Forward P/E	17.47	36.29
PEG ratio	8.52	2.05
P/S ratio	5.71	12.55
P/B ratio	18.61	7.62
EV / EBITDA	N/A	32.07
FCF yield	4.68%	2.33%

Profitability

Metric	AMGN	ISRG
Gross margin	72.65%	66.68%
Operating margin	33.18%	31.28%
Net margin	22.93%	28.45%
ROE	74.80%	17.28%
ROIC	14.22%	15.11%

Dividends

Metric	AMGN	ISRG
Dividend yield	2.47%	N/A
Payout ratio	61.78%	N/A

Growth (annualized)

Metric	AMGN	ISRG
Revenue CAGR (5Y)	8.39%	16.41%
EPS CAGR (5Y)	2.94%	21.51%
FCF CAGR (5Y)	-3.91%	14.17%
Total return CAGR (5Y)	17.09%	3.10%

Frequently asked

Which has the lower trailing P/E, AMGN or ISRG?: AMGN has the lower trailing P/E: AMGN trades at 25.05 and ISRG at 44.59. P/E is one valuation measure and does not by itself establish which business is cheaper.
Which has grown faster, AMGN or ISRG?: Over the past five years, ISRG grew revenue faster — AMGN at a 8.39% CAGR versus ISRG at 16.41%.
Does AMGN or ISRG pay a bigger dividend?: AMGN pays a dividend (2.47% yield), while ISRG has no payments in the available dividend history.
Is AMGN or ISRG more profitable?: ISRG runs the higher net margin — AMGN at 22.93% versus ISRG at 28.45%.
How have AMGN and ISRG total returns compared?: Over the past 10 years, AMGN delivered 12.52% and ISRG delivered 17.14% annualized total return. Past performance doesn't predict future results.

Go deeper

Full AMGN analysis Full ISRG analysis Interactive comparison tool

Dig into the metrics

Amgen P/E ratio Intuitive Surgical P/E ratio Amgen dividend yield Amgen ROE Intuitive Surgical ROE Amgen operating margin Intuitive Surgical operating margin Amgen revenue growth Intuitive Surgical revenue growth Amgen free cash flow Intuitive Surgical free cash flow

Amgen & Intuitive Surgical appear in these rankings

Highest Dividend Yield Stocks Fastest Revenue Growth Stocks Highest ROE Stocks Highest Operating Margin Stocks

Figures are sourced from reported fundamentals and the latest end-of-day price. This comparison is informational only and is not investment advice. Past performance does not predict future results. See our methodology. Compiled by TGMCharts Research · data verified October 4, 2026.