Is AMGN or ISRG cheaper?

On trailing earnings, AMGN is cheaper: AMGN trades at a 24.21 P/E and ISRG at 50.55.

Which has grown faster, AMGN or ISRG?

Over the past five years, ISRG grew revenue faster — AMGN at a 8.15% CAGR versus ISRG at 18.39%.

Does AMGN or ISRG pay a bigger dividend?

AMGN pays a dividend (2.82% yield) while ISRG does not currently pay one.

Is AMGN or ISRG more profitable?

ISRG runs the higher net margin — AMGN at 20.95% versus ISRG at 28.15%.

Which has been the better investment, AMGN or ISRG?

Over the past 10-year, ISRG delivered the higher annualized total return — AMGN at 12.07% versus ISRG at 19.26%. Past performance doesn't predict future results.

Amgen Inc. (AMGN) vs Intuitive Surgical, Inc. (ISRG)

AMGN leads on 10 of 16 compared metrics.

A side-by-side comparison of Amgen Inc. and Intuitive Surgical, Inc. across valuation, profitability, dividends, and growth — built entirely from reported fundamentals, as of June 17, 2026. The ● marks the stronger figure on each row (cheaper multiple, higher margin/return).

Intuitive Surgical, Inc.

$145.70B

$417.07Healthcare

Total return — AMGN vs ISRG

growth of $100 · last 26y

AMGN +410.6%ISRG +20342.9%ISRG compounded faster

Log scale — wide-divergence pair

AMGN ISRG

AMGN vs ISRG: by the numbers

•AMGN is the larger company ($187.59B vs $145.70B market cap).
•AMGN trades at the lower earnings multiple (24.21 vs 50.55 P/E).
•ISRG converts more revenue to profit (28.15% vs 20.95% net margin).
•ISRG grew revenue faster over the past five years (18.39% vs 8.15% CAGR).
•AMGN pays a dividend (2.82% yield) while ISRG does not currently pay one.

Which is better, AMGN or ISRG?

Metric tally: AMGN 10 · ISRG 6

It depends on what you're optimizing for:

ValueAMGN(lower P/E)

GrowthISRG(faster 5Y revenue CAGR)

QualityISRG(higher ROIC)

Metrics side by side

Valuation

Metric	AMGN	ISRG
P/E ratio	24.21●	50.55
Forward P/E	14.83●	35.43
P/S ratio	5.08●	14.18
P/B ratio	20.59	8.59●
PEG ratio	0.26●	3.17
EV / EBITDA	14.05●	34.27
FCF yield	4.54%●	1.89%

Profitability

Metric	AMGN	ISRG
Gross margin	71.46%●	66.29%
Operating margin	31.63%●	30.45%
Net margin	20.95%	28.15%●
ROE	84.87%●	17.05%
ROIC	13.16%	13.71%●

Dividends

Metric	AMGN	ISRG
Dividend yield	2.82%	—
Payout ratio	68.39%	—

Growth (annualized)

Metric	AMGN	ISRG
Revenue CAGR (5Y)	8.15%	18.39%●
EPS CAGR (5Y)	2.94%	21.51%●
FCF CAGR (5Y)	-2.66%	16.61%●
Total return CAGR (5Y)	11.05%●	7.06%

Frequently asked

Which is better, AMGN or ISRG?: It depends on your goal. value: AMGN (lower P/E); growth: ISRG (faster 5Y revenue CAGR); quality: ISRG (higher ROIC). Across all compared metrics, AMGN leads 10 to 6.
Is AMGN or ISRG cheaper?: On trailing earnings, AMGN is cheaper: AMGN trades at a 24.21 P/E and ISRG at 50.55.
Which has grown faster, AMGN or ISRG?: Over the past five years, ISRG grew revenue faster — AMGN at a 8.15% CAGR versus ISRG at 18.39%.
Does AMGN or ISRG pay a bigger dividend?: AMGN pays a dividend (2.82% yield) while ISRG does not currently pay one.
Is AMGN or ISRG more profitable?: ISRG runs the higher net margin — AMGN at 20.95% versus ISRG at 28.15%.
Which has been the better investment, AMGN or ISRG?: Over the past 10-year, ISRG delivered the higher annualized total return — AMGN at 12.07% versus ISRG at 19.26%. Past performance doesn't predict future results.

Go deeper

Full AMGN analysis Full ISRG analysis Interactive comparison tool

Dig into the metrics

Amgen P/E ratio Intuitive Surgical P/E ratio Amgen dividend yield Intuitive Surgical dividend yield Amgen ROE Intuitive Surgical ROE Amgen operating margin Intuitive Surgical operating margin Amgen revenue growth Intuitive Surgical revenue growth Amgen free cash flow Intuitive Surgical free cash flow

Amgen & Intuitive Surgical appear in these rankings

Highest Dividend Yield Stocks Fastest Revenue Growth Stocks Highest ROE Stocks Highest Operating Margin Stocks

Figures are sourced from reported fundamentals and the latest end-of-day price. This comparison is informational only and is not investment advice. Past performance does not predict future results. See our methodology. Compiled by TGMCharts Research · data verified June 17, 2026.