Amgen Inc. (AMGN) vs AstraZeneca PLC (AZN)

AZN leads on 8 of 15 compared metrics, though AMGN is the cheaper stock.

A side-by-side comparison of Amgen Inc. and AstraZeneca PLC across valuation, profitability, dividends, and growth — built entirely from reported fundamentals, as of June 13, 2026. The ● marks the stronger figure on each row (cheaper multiple, higher margin/return).

Total return — AMGN vs AZN

growth of $100 · last 30y
AMGN +2282.3%AZN +723.4%AMGN compounded faster
01k2kStart $100200120062011201620212026$2,382$823
AMGN AZN

AMGN vs AZN: by the numbers

  • AZN is the larger company ($277.22B vs $191.70B market cap).
  • AMGN trades at the lower earnings multiple (24.72 vs 26.92 P/E).
  • AMGN converts more revenue to profit (20.95% vs 17.19% net margin).
  • AZN grew revenue faster over the past five years (16.99% vs 8.15% CAGR).
  • AMGN pays the higher dividend yield (2.76% vs 1.79%).

Which is better, AMGN or AZN?

Metric tally: AMGN 7 · AZN 8

It depends on what you're optimizing for:

ValueAMGN(lower P/E)
GrowthAZN(faster 5Y revenue CAGR)
IncomeAMGN(higher dividend yield)

Valuation

MetricAMGNAZN
P/E ratio24.7226.92
Forward P/E15.1515.33
P/S ratio5.194.62
P/B ratio21.035.90
PEG ratio0.260.14
EV / EBITDA15.3214.92
FCF yield4.45%3.26%

Profitability

MetricAMGNAZN
Gross margin71.46%81.68%
Operating margin31.63%23.69%
Net margin20.95%17.19%
ROE84.87%21.95%
ROIC13.16%13.03%

Dividends

MetricAMGNAZN
Dividend yield2.76%1.79%
Payout ratio68.39%48.48%

Growth (annualized)

MetricAMGNAZN
Revenue CAGR (5Y)8.15%16.99%
EPS CAGR (5Y)2.94%22.02%
FCF CAGR (5Y)-2.66%18.52%
Total return CAGR (5Y)11.36%11.03%

Frequently asked

Which is better, AMGN or AZN?
It depends on your goal. value: AMGN (lower P/E); growth: AZN (faster 5Y revenue CAGR); income: AMGN (higher dividend yield). Across all compared metrics, AZN leads 8 to 7.
Is AMGN or AZN cheaper?
On trailing earnings, AMGN is cheaper: AMGN trades at a 24.72 P/E and AZN at 26.92.
Which has grown faster, AMGN or AZN?
Over the past five years, AZN grew revenue faster — AMGN at a 8.15% CAGR versus AZN at 16.99%.
Does AMGN or AZN pay a bigger dividend?
AMGN yields 2.76% and AZN yields 1.79% based on trailing dividends and the latest price.
Is AMGN or AZN more profitable?
AMGN runs the higher net margin — AMGN at 20.95% versus AZN at 17.19%.
Which has been the better investment, AMGN or AZN?
Over the past 10-year, AZN delivered the higher annualized total return — AMGN at 11.94% versus AZN at 15.77%. Past performance doesn't predict future results.

Figures are sourced from reported fundamentals and the latest end-of-day price. This comparison is informational only and is not investment advice. Past performance does not predict future results. See our methodology. Compiled by TGMCharts Research · data verified June 13, 2026.