How have ALXO and CUE total returns compared?

Over the past 5 years, ALXO delivered -56.07% and CUE delivered -42.42% annualized total return. Past performance doesn't predict future results.

ALX Oncology Holdings Inc. (ALXO) vs Cue Biopharma, Inc. (CUE)

A side-by-side comparison of ALX Oncology Holdings Inc. and Cue Biopharma, Inc. across valuation, profitability, dividends, and growth — built entirely from reported fundamentals, as of October 6, 2026. Differences are shown without an overall score or investment verdict.

ALXO

ALX Oncology Holdings Inc.

$163M

$1.21HealthcareDelayed quote: Oct 5, 2026, 4:00 PM EDT

CUE

Cue Biopharma, Inc.

$177M

$24.36HealthcareDelayed quote: Oct 5, 2026, 4:00 PM EDT

Total return — ALXO vs CUE

growth of $100 · dividends reinvested · last 6y

ALXO -96.0% (-41.4%/yr)CUE -96.3% (-42.4%/yr)ALXO compounded faster over this window

ALXO CUE

ALXO vs CUE: by the numbers

•CUE is the larger company ($177M vs $163M market cap).
•Both run net losses; ALXO's is the smaller (0.00% vs -435.83% net margin).

Metrics side by side

Valuation

Metric	ALXO	CUE
P/S ratio	N/A	4.70
P/B ratio	1.20	76.61

Profitability

Metric	ALXO	CUE
Gross margin	0.00%	99.69%
Operating margin	0.00%	-96.56%
Net margin	0.00%	-435.83%
ROE	-59.40%	-7104.24%
ROIC	-56.53%	-1039.56%

Growth (annualized)

Metric	ALXO	CUE
Revenue CAGR (5Y)	N/A	47.08%
Total return CAGR (5Y)	-56.07%	-42.42%

Frequently asked

How have ALXO and CUE total returns compared?: Over the past 5 years, ALXO delivered -56.07% and CUE delivered -42.42% annualized total return. Past performance doesn't predict future results.

Go deeper

Full ALXO analysis Full CUE analysis Interactive comparison tool

Dig into the metrics

ALX Oncology ROE Cue Biopharma ROE ALX Oncology operating margin Cue Biopharma operating margin ALX Oncology revenue growth Cue Biopharma revenue growth ALX Oncology free cash flow Cue Biopharma free cash flow

ALX Oncology & Cue Biopharma appear in these rankings

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Figures are sourced from reported fundamentals and the latest end-of-day price. This comparison is informational only and is not investment advice. Past performance does not predict future results. See our methodology. Compiled by TGMCharts Research · data verified October 6, 2026.