Which has the lower trailing P/E, ALNY or WAT?

ALNY has the lower trailing P/E: ALNY trades at 41.01 and WAT at 105.02. P/E is one valuation measure and does not by itself establish which business is cheaper.

Which has grown faster, ALNY or WAT?

Over the past five years, ALNY grew revenue faster — ALNY at a 47.53% CAGR versus WAT at 11.70%.

Is ALNY or WAT more profitable?

ALNY runs the higher net margin — ALNY at 16.82% versus WAT at 3.58%.

How have ALNY and WAT total returns compared?

Over the past 10 years, ALNY delivered 13.54% and WAT delivered 10.36% annualized total return. Past performance doesn't predict future results.

Alnylam Pharmaceuticals, Inc. (ALNY) vs Waters Corporation (WAT)

A side-by-side comparison of Alnylam Pharmaceuticals, Inc. and Waters Corporation across valuation, profitability, dividends, and growth — built entirely from reported fundamentals, as of September 13, 2026. Differences are shown without an overall score or investment verdict.

ALNY

Alnylam Pharmaceuticals, Inc.

$32.49B

$242.78HealthcareDelayed quote: Sep 15, 2026, 2:20 PM EDT

WAT

Waters Corporation

$31.50B

$421.12HealthcareDelayed quote: Sep 15, 2026, 2:20 PM EDT

Total return — ALNY vs WAT

growth of $100 · dividends reinvested · last 10y

ALNY +247.1% (+13.3%/yr)WAT +154.2% (+9.8%/yr)ALNY compounded faster over this window

ALNY WAT

ALNY vs WAT: by the numbers

•ALNY is the larger company ($32.49B vs $31.50B market cap).
•ALNY trades at the lower trailing earnings multiple (41.01 vs 105.02 P/E), one valuation lens rather than an overall verdict.
•ALNY converts more revenue to profit (16.82% vs 3.58% net margin).
•ALNY grew revenue faster over the past five years (47.53% vs 11.70% CAGR).

Metrics side by side

Valuation

Metric	ALNY	WAT
P/E ratio	41.01	105.02
Forward P/E	36.38	28.90
P/S ratio	6.76	6.78
P/B ratio	23.99	2.07
EV / EBITDA	30.40	39.02
FCF yield	1.67%	1.27%

Profitability

Metric	ALNY	WAT
Gross margin	79.72%	50.78%
Operating margin	20.81%	28.22%
Net margin	16.82%	3.58%
ROE	59.67%	1.09%
ROIC	24.71%	1.34%

Growth (annualized)

Metric	ALNY	WAT
Revenue CAGR (5Y)	47.53%	11.70%
EPS CAGR (5Y)	N/A	5.16%
FCF CAGR (5Y)	N/A	-9.10%
Total return CAGR (5Y)	5.58%	-0.83%

Frequently asked

Which has the lower trailing P/E, ALNY or WAT?: ALNY has the lower trailing P/E: ALNY trades at 41.01 and WAT at 105.02. P/E is one valuation measure and does not by itself establish which business is cheaper.
Which has grown faster, ALNY or WAT?: Over the past five years, ALNY grew revenue faster — ALNY at a 47.53% CAGR versus WAT at 11.70%.
Is ALNY or WAT more profitable?: ALNY runs the higher net margin — ALNY at 16.82% versus WAT at 3.58%.
How have ALNY and WAT total returns compared?: Over the past 10 years, ALNY delivered 13.54% and WAT delivered 10.36% annualized total return. Past performance doesn't predict future results.

Go deeper

Full ALNY analysis Full WAT analysis Interactive comparison tool

Dig into the metrics

Alnylam Pharmaceuticals P/E ratio Waters P/E ratio Alnylam Pharmaceuticals ROE Waters ROE Alnylam Pharmaceuticals operating margin Waters operating margin Alnylam Pharmaceuticals revenue growth Waters revenue growth Alnylam Pharmaceuticals free cash flow Waters free cash flow

Alnylam Pharmaceuticals & Waters appear in these rankings

Fastest Revenue Growth Stocks Highest ROE Stocks Highest ROIC Stocks Highest 10-Year Total Return Stocks

Figures are sourced from reported fundamentals and the latest end-of-day price. This comparison is informational only and is not investment advice. Past performance does not predict future results. See our methodology. Compiled by TGMCharts Research · data verified September 13, 2026.