Is ALKS or PRAX more profitable?

ALKS runs the higher net margin — ALKS at 3.97% versus PRAX at 0.00%.

How have ALKS and PRAX total returns compared?

Over the past 5 years, ALKS delivered 6.73% and PRAX delivered -0.21% annualized total return. Past performance doesn't predict future results.

Alkermes plc (ALKS) vs Praxis Precision Medicines, Inc. (PRAX)

A side-by-side comparison of Alkermes plc and Praxis Precision Medicines, Inc. across valuation, profitability, dividends, and growth — built entirely from reported fundamentals, as of October 6, 2026. Differences are shown without an overall score or investment verdict.

ALKS

Alkermes plc

$6.95B

$41.46HealthcareDelayed quote: Oct 6, 2026, 1:20 PM EDT

PRAX

Praxis Precision Medicines, Inc.

$7.63B

$273.80HealthcareDelayed quote: Oct 6, 2026, 1:15 PM EDT

Total return — ALKS vs PRAX

growth of $100 · dividends reinvested · last 6y

ALKS +149.6% (+16.5%/yr)PRAX -32.0% (-6.2%/yr)ALKS compounded faster over this window

ALKS PRAX

ALKS vs PRAX: by the numbers

•PRAX is the larger company ($7.63B vs $6.95B market cap).
•ALKS is profitable (3.97% net margin) while PRAX runs a net loss (0.00%).

Metrics side by side

Valuation

Metric	ALKS	PRAX
P/E ratio	108.24	N/A
P/S ratio	4.17	N/A
P/B ratio	3.85	5.69
EV / EBITDA	44.80	N/A
FCF yield	3.19%	N/A

Profitability

Metric	ALKS	PRAX
Gross margin	84.56%	0.00%
Operating margin	17.21%	0.00%
Net margin	3.97%	0.00%
ROE	3.66%	-25.29%
ROIC	2.12%	-28.18%

Growth (annualized)

Metric	ALKS	PRAX
Revenue CAGR (5Y)	8.68%	N/A
FCF CAGR (5Y)	20.00%	N/A
Total return CAGR (5Y)	6.73%	-0.21%

Frequently asked

Is ALKS or PRAX more profitable?: ALKS runs the higher net margin — ALKS at 3.97% versus PRAX at 0.00%.
How have ALKS and PRAX total returns compared?: Over the past 5 years, ALKS delivered 6.73% and PRAX delivered -0.21% annualized total return. Past performance doesn't predict future results.

Go deeper

Full ALKS analysis Full PRAX analysis Interactive comparison tool

Dig into the metrics

Alkermes P/E ratio Alkermes ROE Praxis Precision Medicines ROE Alkermes operating margin Praxis Precision Medicines operating margin Alkermes revenue growth Praxis Precision Medicines revenue growth Alkermes free cash flow Praxis Precision Medicines free cash flow

Figures are sourced from reported fundamentals and the latest end-of-day price. This comparison is informational only and is not investment advice. Past performance does not predict future results. See our methodology. Compiled by TGMCharts Research · data verified October 6, 2026.