Which has grown faster, ALGN or TWST?

Over the past five years, TWST grew revenue faster — ALGN at a 3.57% CAGR versus TWST at 27.77%.

Is ALGN or TWST more profitable?

ALGN runs the higher net margin — ALGN at 9.99% versus TWST at -31.66%.

How have ALGN and TWST total returns compared?

Over the past 5 years, ALGN delivered -26.34% and TWST delivered 15.59% annualized total return. Past performance doesn't predict future results.

Align Technology, Inc. (ALGN) vs Twist Bioscience Corporation (TWST)

A side-by-side comparison of Align Technology, Inc. and Twist Bioscience Corporation across valuation, profitability, dividends, and growth — built entirely from reported fundamentals, as of October 6, 2026. Differences are shown without an overall score or investment verdict.

ALGN

Align Technology, Inc.

$10.13B

$141.45HealthcareDelayed quote: Oct 6, 2026, 4:00 PM EDT

TWST

Twist Bioscience Corporation

$10.40B

$166.97HealthcareDelayed quote: Oct 6, 2026, 4:00 PM EDT

Total return — ALGN vs TWST

growth of $100 · dividends reinvested · last 8y

ALGN -36.9% (-5.6%/yr)TWST +1364.3% (+39.9%/yr)TWST compounded faster over this window

Log scale — wide-divergence pair

ALGN TWST

ALGN vs TWST: by the numbers

•TWST is the larger company ($10.40B vs $10.13B market cap).
•ALGN is profitable (9.99% net margin) while TWST runs a net loss (-31.66%).
•TWST grew revenue faster over the past five years (27.77% vs 3.57% CAGR).

Metrics side by side

Valuation

Metric	ALGN	TWST
P/E ratio	24.56	N/A
Forward P/E	12.55	N/A
P/S ratio	2.45	24.08
P/B ratio	2.39	23.33
EV / EBITDA	11.35	N/A

Profitability

Metric	ALGN	TWST
Gross margin	66.48%	51.97%
Operating margin	13.33%	-31.91%
Net margin	9.99%	-31.66%
ROE	9.77%	-30.67%
ROIC	8.90%	-24.57%

Growth (annualized)

Metric	ALGN	TWST
Revenue CAGR (5Y)	3.57%	27.77%
EPS CAGR (5Y)	-24.16%	N/A
Total return CAGR (5Y)	-26.34%	15.59%

Some values include inputs from SEC filing.

Frequently asked

Which has grown faster, ALGN or TWST?: Over the past five years, TWST grew revenue faster — ALGN at a 3.57% CAGR versus TWST at 27.77%.
Is ALGN or TWST more profitable?: ALGN runs the higher net margin — ALGN at 9.99% versus TWST at -31.66%.
How have ALGN and TWST total returns compared?: Over the past 5 years, ALGN delivered -26.34% and TWST delivered 15.59% annualized total return. Past performance doesn't predict future results.

Go deeper

Full ALGN analysis Full TWST analysis Interactive comparison tool

Dig into the metrics

Align Technology P/E ratio Align Technology ROE Twist Bioscience ROE Align Technology operating margin Twist Bioscience operating margin Align Technology revenue growth Twist Bioscience revenue growth Align Technology free cash flow Twist Bioscience free cash flow

Align Technology & Twist Bioscience appear in these rankings

Fastest Revenue Growth Stocks

Figures are sourced from reported fundamentals and the latest end-of-day price. This comparison is informational only and is not investment advice. Past performance does not predict future results. See our methodology. Compiled by TGMCharts Research · data verified October 6, 2026.