Which has the lower trailing P/E, ALGN or RGEN?

ALGN has the lower trailing P/E: ALGN trades at 24.56 and RGEN at 239.53. P/E is one valuation measure and does not by itself establish which business is cheaper.

Which has grown faster, ALGN or RGEN?

Over the past five years, RGEN grew revenue faster — ALGN at a 3.57% CAGR versus RGEN at 9.08%.

Is ALGN or RGEN more profitable?

ALGN runs the higher net margin — ALGN at 9.99% versus RGEN at 5.29%.

How have ALGN and RGEN total returns compared?

Over the past 10 years, ALGN delivered 4.63% and RGEN delivered 20.13% annualized total return. Past performance doesn't predict future results.

Align Technology, Inc. (ALGN) vs Repligen Corporation (RGEN)

A side-by-side comparison of Align Technology, Inc. and Repligen Corporation across valuation, profitability, dividends, and growth — built entirely from reported fundamentals, as of October 6, 2026. Differences are shown without an overall score or investment verdict.

ALGN

Align Technology, Inc.

$10.13B

$141.45HealthcareDelayed quote: Oct 6, 2026, 4:00 PM EDT

RGEN

Repligen Corporation

$9.87B

$174.86HealthcareDelayed quote: Oct 6, 2026, 4:00 PM EDT

Total return — ALGN vs RGEN

growth of $100 · dividends reinvested · last 10y

ALGN +54.4% (+4.4%/yr)RGEN +528.7% (+20.2%/yr)RGEN compounded faster over this window

ALGN RGEN

ALGN vs RGEN: by the numbers

•ALGN is the larger company ($10.13B vs $9.87B market cap).
•ALGN trades at the lower trailing earnings multiple (24.56 vs 239.53 P/E), one valuation lens rather than an overall verdict.
•ALGN converts more revenue to profit (9.99% vs 5.29% net margin).
•RGEN grew revenue faster over the past five years (9.08% vs 3.57% CAGR).

Metrics side by side

Valuation

Metric	ALGN	RGEN
P/E ratio	24.56	239.53
Forward P/E	12.55	84.92
P/S ratio	2.45	12.57
P/B ratio	2.39	4.67
EV / EBITDA	11.35	67.03
FCF yield	N/A	1.12%

Profitability

Metric	ALGN	RGEN
Gross margin	66.48%	51.05%
Operating margin	13.33%	8.32%
Net margin	9.99%	5.29%
ROE	9.77%	1.97%
ROIC	8.90%	1.85%

Growth (annualized)

Metric	ALGN	RGEN
Revenue CAGR (5Y)	3.57%	9.08%
EPS CAGR (5Y)	-24.16%	-5.26%
FCF CAGR (5Y)	N/A	22.49%
Total return CAGR (5Y)	-26.34%	-6.86%

Some values include inputs from SEC filing.

Frequently asked

Which has the lower trailing P/E, ALGN or RGEN?: ALGN has the lower trailing P/E: ALGN trades at 24.56 and RGEN at 239.53. P/E is one valuation measure and does not by itself establish which business is cheaper.
Which has grown faster, ALGN or RGEN?: Over the past five years, RGEN grew revenue faster — ALGN at a 3.57% CAGR versus RGEN at 9.08%.
Is ALGN or RGEN more profitable?: ALGN runs the higher net margin — ALGN at 9.99% versus RGEN at 5.29%.
How have ALGN and RGEN total returns compared?: Over the past 10 years, ALGN delivered 4.63% and RGEN delivered 20.13% annualized total return. Past performance doesn't predict future results.

Go deeper

Full ALGN analysis Full RGEN analysis Interactive comparison tool

Dig into the metrics

Align Technology P/E ratio Repligen P/E ratio Align Technology ROE Repligen ROE Align Technology operating margin Repligen operating margin Align Technology revenue growth Repligen revenue growth Align Technology free cash flow Repligen free cash flow

Align Technology & Repligen appear in these rankings

Highest 10-Year Total Return Stocks

Figures are sourced from reported fundamentals and the latest end-of-day price. This comparison is informational only and is not investment advice. Past performance does not predict future results. See our methodology. Compiled by TGMCharts Research · data verified October 6, 2026.