Is ALGN or MDGL more profitable?

ALGN runs the higher net margin — ALGN at 9.99% versus MDGL at -25.32%.

How have ALGN and MDGL total returns compared?

Over the past 10 years, ALGN delivered 4.63% and MDGL delivered 41.50% annualized total return. Past performance doesn't predict future results.

Align Technology, Inc. (ALGN) vs Madrigal Pharmaceuticals, Inc. (MDGL)

A side-by-side comparison of Align Technology, Inc. and Madrigal Pharmaceuticals, Inc. across valuation, profitability, dividends, and growth — built entirely from reported fundamentals, as of October 5, 2026. Differences are shown without an overall score or investment verdict.

ALGN

Align Technology, Inc.

$10.21B

$142.60HealthcareDelayed quote: Oct 6, 2026, 11:31 AM EDT

MDGL

Madrigal Pharmaceuticals, Inc.

$11.58B

$501.32HealthcareDelayed quote: Oct 6, 2026, 11:31 AM EDT

Total return — ALGN vs MDGL

growth of $100 · dividends reinvested · last 10y

ALGN +52.2% (+4.3%/yr)MDGL +2930.2% (+40.7%/yr)MDGL compounded faster over this window

Log scale — wide-divergence pair

ALGN MDGL

ALGN vs MDGL: by the numbers

•MDGL is the larger company ($11.58B vs $10.21B market cap).
•ALGN is profitable (9.99% net margin) while MDGL runs a net loss (-25.32%).

Metrics side by side

Valuation

Metric	ALGN	MDGL
P/E ratio	24.76	N/A
Forward P/E	12.63	N/A
P/S ratio	2.47	9.02
P/B ratio	2.41	22.12
EV / EBITDA	11.45	N/A

Profitability

Metric	ALGN	MDGL
Gross margin	66.48%	91.48%
Operating margin	13.33%	-25.13%
Net margin	9.99%	-25.32%
ROE	9.77%	-62.07%
ROIC	8.90%	-37.02%

Growth (annualized)

Metric	ALGN	MDGL
Revenue CAGR (5Y)	3.57%	N/A
EPS CAGR (5Y)	-24.16%	N/A
Total return CAGR (5Y)	-26.34%	44.41%

Some values include inputs from SEC filing.

Frequently asked

Is ALGN or MDGL more profitable?: ALGN runs the higher net margin — ALGN at 9.99% versus MDGL at -25.32%.
How have ALGN and MDGL total returns compared?: Over the past 10 years, ALGN delivered 4.63% and MDGL delivered 41.50% annualized total return. Past performance doesn't predict future results.

Go deeper

Full ALGN analysis Full MDGL analysis Interactive comparison tool

Dig into the metrics

Align Technology P/E ratio Align Technology ROE Madrigal Pharmaceuticals ROE Align Technology operating margin Madrigal Pharmaceuticals operating margin Align Technology revenue growth Madrigal Pharmaceuticals revenue growth Align Technology free cash flow Madrigal Pharmaceuticals free cash flow

Align Technology & Madrigal Pharmaceuticals appear in these rankings

Highest 10-Year Total Return Stocks

Figures are sourced from reported fundamentals and the latest end-of-day price. This comparison is informational only and is not investment advice. Past performance does not predict future results. See our methodology. Compiled by TGMCharts Research · data verified October 5, 2026.