Which has the lower trailing P/E, ALGN or EXEL?

EXEL has the lower trailing P/E: ALGN trades at 27.59 and EXEL at 16.95. P/E is one valuation measure and does not by itself establish which business is cheaper.

Which has grown faster, ALGN or EXEL?

Over the past five years, EXEL grew revenue faster — ALGN at a 3.57% CAGR versus EXEL at 16.06%.

Is ALGN or EXEL more profitable?

EXEL runs the higher net margin — ALGN at 9.99% versus EXEL at 35.33%.

How have ALGN and EXEL total returns compared?

Over the past 10 years, ALGN delivered 5.30% and EXEL delivered 17.26% annualized total return. Past performance doesn't predict future results.

Align Technology, Inc. (ALGN) vs Exelixis, Inc. (EXEL)

A side-by-side comparison of Align Technology, Inc. and Exelixis, Inc. across valuation, profitability, dividends, and growth — built entirely from reported fundamentals, as of August 21, 2026. Differences are shown without an overall score or investment verdict.

ALGN

Align Technology, Inc.

$11.64B

$162.55HealthcareDelayed quote: Aug 21, 2026, 4:00 PM EDT

EXEL

Exelixis, Inc.

$13.59B

$54.08HealthcareDelayed quote: Aug 21, 2026, 4:00 PM EDT

Total return — ALGN vs EXEL

growth of $100 · dividends reinvested · last 10y

ALGN +67.6% (+5.3%/yr)EXEL +384.7% (+17.1%/yr)EXEL compounded faster over this window

ALGN EXEL

ALGN vs EXEL: by the numbers

•EXEL is the larger company ($13.59B vs $11.64B market cap).
•EXEL trades at the lower trailing earnings multiple (16.95 vs 27.59 P/E), one valuation lens rather than an overall verdict.
•EXEL converts more revenue to profit (35.33% vs 9.99% net margin).
•EXEL grew revenue faster over the past five years (16.06% vs 3.57% CAGR).

Metrics side by side

Valuation

Metric	ALGN	EXEL
P/E ratio	27.59	16.95
Forward P/E	14.08	18.14
P/S ratio	2.75	5.77
P/B ratio	2.69	7.62
EV / EBITDA	14.66	13.93
FCF yield	6.64%	8.41%

Profitability

Metric	ALGN	EXEL
Gross margin	66.48%	96.48%
Operating margin	13.33%	39.88%
Net margin	9.99%	35.33%
ROE	9.77%	46.68%
ROIC	8.90%	37.87%

Growth (annualized)

Metric	ALGN	EXEL
Revenue CAGR (5Y)	3.57%	16.06%
EPS CAGR (5Y)	-24.16%	51.51%
FCF CAGR (5Y)	-3.33%	40.17%
Total return CAGR (5Y)	-25.26%	24.00%

Frequently asked

Which has the lower trailing P/E, ALGN or EXEL?: EXEL has the lower trailing P/E: ALGN trades at 27.59 and EXEL at 16.95. P/E is one valuation measure and does not by itself establish which business is cheaper.
Which has grown faster, ALGN or EXEL?: Over the past five years, EXEL grew revenue faster — ALGN at a 3.57% CAGR versus EXEL at 16.06%.
Is ALGN or EXEL more profitable?: EXEL runs the higher net margin — ALGN at 9.99% versus EXEL at 35.33%.
How have ALGN and EXEL total returns compared?: Over the past 10 years, ALGN delivered 5.30% and EXEL delivered 17.26% annualized total return. Past performance doesn't predict future results.

Go deeper

Full ALGN analysis Full EXEL analysis Interactive comparison tool

Dig into the metrics

Align Technology P/E ratio Exelixis P/E ratio Align Technology ROE Exelixis ROE Align Technology operating margin Exelixis operating margin Align Technology revenue growth Exelixis revenue growth Align Technology free cash flow Exelixis free cash flow

Align Technology & Exelixis appear in these rankings

Fastest Revenue Growth Stocks Highest ROE Stocks Highest ROIC Stocks Highest Operating Margin Stocks

Figures are sourced from reported fundamentals and the latest end-of-day price. This comparison is informational only and is not investment advice. Past performance does not predict future results. See our methodology. Compiled by TGMCharts Research · data verified August 21, 2026.