Which has grown faster, ALEC or LYEL?

Neither grew: over the past five years both shrank revenue, with ALEC's decline the smaller — ALEC at a -8.35% CAGR versus LYEL at -68.32%.

How have ALEC and LYEL total returns compared?

Over the past 5 years, ALEC delivered -39.17% and LYEL delivered -48.18% annualized total return. Past performance doesn't predict future results.

Alector, Inc. (ALEC) vs Lyell Immunopharma, Inc. (LYEL)

A side-by-side comparison of Alector, Inc. and Lyell Immunopharma, Inc. across valuation, profitability, dividends, and growth — built entirely from reported fundamentals, as of October 6, 2026. Differences are shown without an overall score or investment verdict.

ALEC

Alector, Inc.

$201M

$1.81HealthcareDelayed quote: Oct 6, 2026, 2:30 PM EDT

LYEL

Lyell Immunopharma, Inc.

$214M

$8.72HealthcareDelayed quote: Oct 6, 2026, 2:25 PM EDT

Total return — ALEC vs LYEL

growth of $100 · dividends reinvested · last 5y

ALEC -90.7% (-37.8%/yr)LYEL -97.3% (-51.5%/yr)ALEC compounded faster over this window

ALEC LYEL

ALEC vs LYEL: by the numbers

•LYEL is the larger company ($214M vs $201M market cap).
•Both run net losses; ALEC's is the smaller (-850.13% vs -920285.19% net margin).
•Both shrank revenue over the past five years; ALEC's decline was smaller (-8.35% vs -68.32% CAGR).

Metrics side by side

Valuation

Metric	ALEC	LYEL
P/S ratio	14.50	7915.27
P/B ratio	N/A	0.91

Profitability

Metric	ALEC	LYEL
Gross margin	54.09%	-31952.78%
Operating margin	-692.83%	-566038.89%
Net margin	-850.13%	-920285.19%
ROE	N/A	-106.27%
ROIC	-71.04%	-70.80%

Growth (annualized)

Metric	ALEC	LYEL
Revenue CAGR (5Y)	-8.35%	-68.32%
Total return CAGR (5Y)	-39.17%	-48.18%

Frequently asked

Which has grown faster, ALEC or LYEL?: Neither grew: over the past five years both shrank revenue, with ALEC's decline the smaller — ALEC at a -8.35% CAGR versus LYEL at -68.32%.
How have ALEC and LYEL total returns compared?: Over the past 5 years, ALEC delivered -39.17% and LYEL delivered -48.18% annualized total return. Past performance doesn't predict future results.

Go deeper

Full ALEC analysis Full LYEL analysis Interactive comparison tool

Dig into the metrics

Alector ROE Lyell Immunopharma ROE Alector operating margin Lyell Immunopharma operating margin Alector revenue growth Lyell Immunopharma revenue growth Alector free cash flow Lyell Immunopharma free cash flow

Figures are sourced from reported fundamentals and the latest end-of-day price. This comparison is informational only and is not investment advice. Past performance does not predict future results. See our methodology. Compiled by TGMCharts Research · data verified October 6, 2026.