Which has grown faster, AGEN or OBIO?

Over the past five years, OBIO grew revenue faster — AGEN at a 14.13% CAGR versus OBIO at 148.45%.

Is AGEN or OBIO more profitable?

AGEN runs the higher net margin — AGEN at 69.34% versus OBIO at -184.60%.

How have AGEN and OBIO total returns compared?

Over the past 5 years, AGEN delivered -40.10% and OBIO delivered -9.35% annualized total return. Past performance doesn't predict future results.

Agenus Inc. (AGEN) vs Orchestra BioMed Holdings, Inc. (OBIO)

A side-by-side comparison of Agenus Inc. and Orchestra BioMed Holdings, Inc. across valuation, profitability, dividends, and growth — built entirely from reported fundamentals, as of October 6, 2026. Differences are shown without an overall score or investment verdict.

AGEN

Agenus Inc.

$324M

$7.78HealthcareDelayed quote: Oct 6, 2026, 1:30 PM EDT

OBIO

Orchestra BioMed Holdings, Inc.

$353M

$5.90HealthcareDelayed quote: Oct 6, 2026, 1:29 PM EDT

Total return — AGEN vs OBIO

growth of $100 · dividends reinvested · last 6y

AGEN -85.4% (-27.4%/yr)OBIO -47.1% (-10.1%/yr)OBIO compounded faster over this window

AGEN OBIO

AGEN vs OBIO: by the numbers

•OBIO is the larger company ($353M vs $324M market cap).
•AGEN is profitable (69.34% net margin) while OBIO runs a net loss (-184.60%).
•OBIO grew revenue faster over the past five years (148.45% vs 14.13% CAGR).

Metrics side by side

Valuation

Metric	AGEN	OBIO
P/E ratio	2.94	N/A
Forward P/E	29.07	N/A
P/S ratio	2.44	11.04
P/B ratio	N/A	18.27
EV / EBITDA	8.45	N/A

Profitability

Metric	AGEN	OBIO
Gross margin	29.63%	99.32%
Operating margin	-18.00%	-154.73%
Net margin	69.34%	-184.60%
ROE	N/A	-200.64%
ROIC	N/A	-56.73%

Growth (annualized)

Metric	AGEN	OBIO
Revenue CAGR (5Y)	14.13%	148.45%
Total return CAGR (5Y)	-40.10%	-9.35%

Frequently asked

Which has grown faster, AGEN or OBIO?: Over the past five years, OBIO grew revenue faster — AGEN at a 14.13% CAGR versus OBIO at 148.45%.
Is AGEN or OBIO more profitable?: AGEN runs the higher net margin — AGEN at 69.34% versus OBIO at -184.60%.
How have AGEN and OBIO total returns compared?: Over the past 5 years, AGEN delivered -40.10% and OBIO delivered -9.35% annualized total return. Past performance doesn't predict future results.

Go deeper

Full AGEN analysis Full OBIO analysis Interactive comparison tool

Dig into the metrics

Agenus P/E ratio Agenus ROE Orchestra BioMed ROE Agenus operating margin Orchestra BioMed operating margin Agenus revenue growth Orchestra BioMed revenue growth Agenus free cash flow Orchestra BioMed free cash flow

Agenus & Orchestra BioMed appear in these rankings

Fastest Revenue Growth Stocks Lowest P/E Ratio Stocks

Figures are sourced from reported fundamentals and the latest end-of-day price. This comparison is informational only and is not investment advice. Past performance does not predict future results. See our methodology. Compiled by TGMCharts Research · data verified October 6, 2026.