Is AGEN or KYTX more profitable?

AGEN runs the higher net margin — AGEN at 69.34% versus KYTX at 0.00%.

Agenus Inc. (AGEN) vs Kyverna Therapeutics, Inc. (KYTX)

A side-by-side comparison of Agenus Inc. and Kyverna Therapeutics, Inc. across valuation, profitability, dividends, and growth — built entirely from reported fundamentals, as of October 6, 2026. Differences are shown without an overall score or investment verdict.

AGEN

Agenus Inc.

$312M

$7.49HealthcareDelayed quote: Oct 6, 2026, 4:00 PM EDT

KYTX

Kyverna Therapeutics, Inc.

$374M

$6.16HealthcareDelayed quote: Oct 6, 2026, 4:00 PM EDT

Total return — AGEN vs KYTX

growth of $100 · dividends reinvested · last 3y

AGEN -34.6% (-13.2%/yr)KYTX -78.9% (-40.5%/yr)AGEN compounded faster over this window

AGEN KYTX

AGEN vs KYTX: by the numbers

•KYTX is the larger company ($374M vs $312M market cap).
•AGEN is profitable (69.34% net margin) while KYTX runs a net loss (0.00%).

Metrics side by side

Valuation

Metric	AGEN	KYTX
P/E ratio	2.83	N/A
Forward P/E	28.00	N/A
P/S ratio	2.35	N/A
P/B ratio	N/A	2.26
EV / EBITDA	8.16	N/A

Profitability

Metric	AGEN	KYTX
Gross margin	29.63%	0.00%
Operating margin	-18.00%	0.00%
Net margin	69.34%	0.00%
ROE	N/A	-92.20%
ROIC	N/A	-80.67%

Growth (annualized)

Metric	AGEN	KYTX
Revenue CAGR (5Y)	14.13%	N/A
Total return CAGR (5Y)	-40.10%	N/A

Frequently asked

Is AGEN or KYTX more profitable?: AGEN runs the higher net margin — AGEN at 69.34% versus KYTX at 0.00%.

Go deeper

Full AGEN analysis Full KYTX analysis Interactive comparison tool

Dig into the metrics

Agenus P/E ratio Agenus ROE Kyverna Therapeutics ROE Agenus operating margin Kyverna Therapeutics operating margin Agenus revenue growth Kyverna Therapeutics revenue growth Agenus free cash flow Kyverna Therapeutics free cash flow

Agenus & Kyverna Therapeutics appear in these rankings

Lowest P/E Ratio Stocks

Figures are sourced from reported fundamentals and the latest end-of-day price. This comparison is informational only and is not investment advice. Past performance does not predict future results. See our methodology. Compiled by TGMCharts Research · data verified October 6, 2026.