Is AGEN or CABA more profitable?

AGEN runs the higher net margin — AGEN at 69.34% versus CABA at 0.00%.

How have AGEN and CABA total returns compared?

Over the past 5 years, AGEN delivered -40.10% and CABA delivered -28.71% annualized total return. Past performance doesn't predict future results.

Agenus Inc. (AGEN) vs Cabaletta Bio, Inc. (CABA)

A side-by-side comparison of Agenus Inc. and Cabaletta Bio, Inc. across valuation, profitability, dividends, and growth — built entirely from reported fundamentals, as of October 6, 2026. Differences are shown without an overall score or investment verdict.

AGEN

Agenus Inc.

$354M

$8.49HealthcareDelayed quote: Oct 6, 2026, 9:30 AM EDT

CABA

Cabaletta Bio, Inc.

$342M

$2.10HealthcareDelayed quote: Oct 6, 2026, 9:30 AM EDT

Total return — AGEN vs CABA

growth of $100 · dividends reinvested · last 7y

AGEN -83.7% (-22.8%/yr)CABA -79.2% (-20.1%/yr)CABA compounded faster over this window

AGEN CABA

AGEN vs CABA: by the numbers

•AGEN is the larger company ($354M vs $342M market cap).
•AGEN is profitable (69.34% net margin) while CABA runs a net loss (0.00%).

Metrics side by side

Valuation

Metric	AGEN	CABA
P/E ratio	3.21	N/A
Forward P/E	31.74	N/A
P/S ratio	2.66	N/A
P/B ratio	N/A	1.63
EV / EBITDA	9.17	N/A

Profitability

Metric	AGEN	CABA
Gross margin	29.63%	0.00%
Operating margin	-18.00%	0.00%
Net margin	69.34%	0.00%
ROE	N/A	-86.10%
ROIC	N/A	-85.56%

Growth (annualized)

Metric	AGEN	CABA
Revenue CAGR (5Y)	14.13%	N/A
Total return CAGR (5Y)	-40.10%	-28.71%

Frequently asked

Is AGEN or CABA more profitable?: AGEN runs the higher net margin — AGEN at 69.34% versus CABA at 0.00%.
How have AGEN and CABA total returns compared?: Over the past 5 years, AGEN delivered -40.10% and CABA delivered -28.71% annualized total return. Past performance doesn't predict future results.

Go deeper

Full AGEN analysis Full CABA analysis Interactive comparison tool

Dig into the metrics

Agenus P/E ratio Agenus ROE Cabaletta Bio ROE Agenus operating margin Cabaletta Bio operating margin Agenus revenue growth Cabaletta Bio revenue growth Agenus free cash flow Cabaletta Bio free cash flow

Agenus & Cabaletta Bio appear in these rankings

Lowest P/E Ratio Stocks

Figures are sourced from reported fundamentals and the latest end-of-day price. This comparison is informational only and is not investment advice. Past performance does not predict future results. See our methodology. Compiled by TGMCharts Research · data verified October 6, 2026.