Aclaris Therapeutics, Inc. (ACRS) vs Ironwood Pharmaceuticals, Inc. (IRWD)
A side-by-side comparison of Aclaris Therapeutics, Inc. and Ironwood Pharmaceuticals, Inc. across valuation, profitability, dividends, and growth — built entirely from reported fundamentals, as of October 6, 2026. Differences are shown without an overall score or investment verdict.
ACRS
Aclaris Therapeutics, Inc.
$3.70HealthcareDelayed quote: Oct 6, 2026, 4:00 PM EDT
IRWD
Ironwood Pharmaceuticals, Inc.
$3.63HealthcareDelayed quote: Oct 6, 2026, 4:00 PM EDT
Total return — ACRS vs IRWD
growth of $100 · dividends reinvested · last 10yACRS -83.0% (-16.2%/yr)IRWD -77.1% (-13.7%/yr)IRWD compounded faster over this window
ACRS IRWD
ACRS vs IRWD: by the numbers
- •IRWD is the larger company ($598M vs $517M market cap).
- •IRWD is profitable (33.36% net margin) while ACRS runs a net loss (-921.50%).
- •ACRS grew revenue faster over the past five years (4.39% vs -1.18% CAGR).
Metrics side by side
Valuation
| Metric | ACRS | IRWD |
|---|---|---|
| P/E ratio | N/A | 4.73 |
| Forward P/E | N/A | 2.97 |
| P/S ratio | 62.87 | 1.53 |
| P/B ratio | 4.15 | N/A |
| EV / EBITDA | N/A | 3.85 |
| FCF yield | N/A | 31.05% |
Profitability
| Metric | ACRS | IRWD |
|---|---|---|
| Gross margin | 73.28% | 99.76% |
| Operating margin | -975.91% | 40.10% |
| Net margin | -921.50% | 33.36% |
| ROE | -60.79% | N/A |
| ROIC | -56.99% | 58.60% |
Growth (annualized)
| Metric | ACRS | IRWD |
|---|---|---|
| Revenue CAGR (5Y) | 4.39% | -1.18% |
| EPS CAGR (5Y) | N/A | -25.87% |
| FCF CAGR (5Y) | N/A | -3.98% |
| Total return CAGR (5Y) | -24.23% | -22.82% |
Frequently asked
- Which has grown faster, ACRS or IRWD?
- Over the past five years, ACRS grew revenue faster — ACRS at a 4.39% CAGR versus IRWD at -1.18%.
- Is ACRS or IRWD more profitable?
- IRWD runs the higher net margin — ACRS at -921.50% versus IRWD at 33.36%.
- How have ACRS and IRWD total returns compared?
- Over the past 10 years, ACRS delivered -16.23% and IRWD delivered -13.70% annualized total return. Past performance doesn't predict future results.
Go deeper
Dig into the metrics
Ironwood Pharmaceuticals P/E ratioAclaris Therapeutics ROEIronwood Pharmaceuticals ROEAclaris Therapeutics operating marginIronwood Pharmaceuticals operating marginAclaris Therapeutics revenue growthIronwood Pharmaceuticals revenue growthAclaris Therapeutics free cash flowIronwood Pharmaceuticals free cash flow
Aclaris Therapeutics & Ironwood Pharmaceuticals appear in these rankings
Figures are sourced from reported fundamentals and the latest end-of-day price. This comparison is informational only and is not investment advice. Past performance does not predict future results. See our methodology. Compiled by TGMCharts Research · data verified October 6, 2026.