AC Immune S.A. (ACIU) vs Upstream Bio, Inc. (UPB)
A side-by-side comparison of AC Immune S.A. and Upstream Bio, Inc. across valuation, profitability, dividends, and growth — built entirely from reported fundamentals, as of October 6, 2026. Differences are shown without an overall score or investment verdict.
ACIU
AC Immune S.A.
$2.52HealthcareDelayed quote: Oct 6, 2026, 4:00 PM EDT
UPB
Upstream Bio, Inc.
$4.59HealthcareDelayed quote: Oct 6, 2026, 4:00 PM EDT
Total return — ACIU vs UPB
growth of $100 · dividends reinvested · last 2yACIU -18.4% (-9.7%/yr)UPB -78.0% (-53.0%/yr)ACIU compounded faster over this window
ACIU UPB
ACIU vs UPB: by the numbers
- •ACIU is the larger company ($256M vs $250M market cap).
- •Both run net losses; ACIU's is the smaller (-249.94% vs -4955.67% net margin).
Metrics side by side
Valuation
| Metric | ACIU | UPB |
|---|---|---|
| P/S ratio | 11.82 | 79.10 |
| P/B ratio | 5.89 | 0.92 |
Profitability
| Metric | ACIU | UPB |
|---|---|---|
| Gross margin | 100.00% | 98.45% |
| Operating margin | -1927.32% | -5618.82% |
| Net margin | -249.94% | -4955.67% |
| ROE | -124.67% | -57.76% |
| ROIC | -89.43% | -62.51% |
Growth (annualized)
| Metric | ACIU | UPB |
|---|---|---|
| Revenue CAGR (5Y) | -23.70% | N/A |
| Total return CAGR (5Y) | -16.03% | N/A |
Go deeper
Dig into the metrics
Figures are sourced from reported fundamentals and the latest end-of-day price. This comparison is informational only and is not investment advice. Past performance does not predict future results. See our methodology. Compiled by TGMCharts Research · data verified October 6, 2026.