Is ACAD or XENE more profitable?

ACAD runs the higher net margin — ACAD at 33.42% versus XENE at -4612.13%.

How have ACAD and XENE total returns compared?

Over the past 10 years, ACAD delivered -3.53% and XENE delivered 17.07% annualized total return. Past performance doesn't predict future results.

Acadia Pharmaceuticals Inc. (ACAD) vs Xenon Pharmaceuticals Inc. (XENE)

A side-by-side comparison of Acadia Pharmaceuticals Inc. and Xenon Pharmaceuticals Inc. across valuation, profitability, dividends, and growth — built entirely from reported fundamentals, as of October 6, 2026. Differences are shown without an overall score or investment verdict.

ACAD

Acadia Pharmaceuticals Inc.

$3.39B

$19.78HealthcareDelayed quote: Oct 6, 2026, 3:10 PM EDT

XENE

Xenon Pharmaceuticals Inc.

$3.51B

$36.35HealthcareDelayed quote: Oct 6, 2026, 3:05 PM EDT

Total return — ACAD vs XENE

growth of $100 · dividends reinvested · last 10y

ACAD -36.8% (-4.5%/yr)XENE +355.4% (+16.4%/yr)XENE compounded faster over this window

Log scale — wide-divergence pair

ACAD XENE

ACAD vs XENE: by the numbers

•XENE is the larger company ($3.51B vs $3.39B market cap).
•ACAD is profitable (33.42% net margin) while XENE runs a net loss (-4612.13%).

Metrics side by side

Valuation

Metric	ACAD	XENE
P/E ratio	8.91	N/A
Forward P/E	32.11	N/A
P/S ratio	2.97	N/A
P/B ratio	2.59	2.83
EV / EBITDA	31.26	N/A
FCF yield	5.15%	N/A

Profitability

Metric	ACAD	XENE
Gross margin	91.13%	66.09%
Operating margin	7.59%	-4974.27%
Net margin	33.42%	-4612.13%
ROE	29.12%	-32.94%
ROIC	6.25%	-35.27%

Growth (annualized)

Metric	ACAD	XENE
Revenue CAGR (5Y)	19.70%	N/A
Total return CAGR (5Y)	3.52%	4.61%

Frequently asked

Is ACAD or XENE more profitable?: ACAD runs the higher net margin — ACAD at 33.42% versus XENE at -4612.13%.
How have ACAD and XENE total returns compared?: Over the past 10 years, ACAD delivered -3.53% and XENE delivered 17.07% annualized total return. Past performance doesn't predict future results.

Go deeper

Full ACAD analysis Full XENE analysis Interactive comparison tool

Dig into the metrics

Acadia Pharmaceuticals P/E ratio Acadia Pharmaceuticals ROE Xenon Pharmaceuticals ROE Acadia Pharmaceuticals operating margin Xenon Pharmaceuticals operating margin Acadia Pharmaceuticals revenue growth Xenon Pharmaceuticals revenue growth Acadia Pharmaceuticals free cash flow Xenon Pharmaceuticals free cash flow

Acadia Pharmaceuticals & Xenon Pharmaceuticals appear in these rankings

Fastest Revenue Growth Stocks Highest ROE Stocks Highest FCF Yield Stocks Highest 10-Year Total Return Stocks

Figures are sourced from reported fundamentals and the latest end-of-day price. This comparison is informational only and is not investment advice. Past performance does not predict future results. See our methodology. Compiled by TGMCharts Research · data verified October 6, 2026.