Is ACAD or DYN more profitable?

ACAD runs the higher net margin — ACAD at 33.42% versus DYN at 0.00%.

How have ACAD and DYN total returns compared?

Over the past 5 years, ACAD delivered 3.52% and DYN delivered -0.38% annualized total return. Past performance doesn't predict future results.

Acadia Pharmaceuticals Inc. (ACAD) vs Dyne Therapeutics, Inc. (DYN)

A side-by-side comparison of Acadia Pharmaceuticals Inc. and Dyne Therapeutics, Inc. across valuation, profitability, dividends, and growth — built entirely from reported fundamentals, as of October 6, 2026. Differences are shown without an overall score or investment verdict.

ACAD

Acadia Pharmaceuticals Inc.

$3.44B

$20.11HealthcareDelayed quote: Oct 5, 2026, 4:00 PM EDT

DYN

Dyne Therapeutics, Inc.

$2.88B

$15.44HealthcareDelayed quote: Oct 5, 2026, 4:00 PM EDT

Total return — ACAD vs DYN

growth of $100 · dividends reinvested · last 6y

ACAD -48.7% (-10.5%/yr)DYN -35.4% (-7.0%/yr)DYN compounded faster over this window

ACAD DYN

ACAD vs DYN: by the numbers

•ACAD is the larger company ($3.44B vs $2.88B market cap).
•ACAD is profitable (33.42% net margin) while DYN runs a net loss (0.00%).

Metrics side by side

Valuation

Metric	ACAD	DYN
P/E ratio	9.06	N/A
Forward P/E	32.65	N/A
P/S ratio	3.02	N/A
P/B ratio	2.64	4.11
EV / EBITDA	31.84	N/A
FCF yield	5.06%	N/A

Profitability

Metric	ACAD	DYN
Gross margin	91.13%	0.00%
Operating margin	7.59%	0.00%
Net margin	33.42%	0.00%
ROE	29.12%	-73.97%
ROIC	6.25%	-58.28%

Growth (annualized)

Metric	ACAD	DYN
Revenue CAGR (5Y)	19.70%	N/A
Total return CAGR (5Y)	3.52%	-0.38%

Frequently asked

Is ACAD or DYN more profitable?: ACAD runs the higher net margin — ACAD at 33.42% versus DYN at 0.00%.
How have ACAD and DYN total returns compared?: Over the past 5 years, ACAD delivered 3.52% and DYN delivered -0.38% annualized total return. Past performance doesn't predict future results.

Go deeper

Full ACAD analysis Full DYN analysis Interactive comparison tool

Dig into the metrics

Acadia Pharmaceuticals P/E ratio Acadia Pharmaceuticals ROE Dyne Therapeutics ROE Acadia Pharmaceuticals operating margin Dyne Therapeutics operating margin Acadia Pharmaceuticals revenue growth Dyne Therapeutics revenue growth Acadia Pharmaceuticals free cash flow Dyne Therapeutics free cash flow

Acadia Pharmaceuticals & Dyne Therapeutics appear in these rankings

Fastest Revenue Growth Stocks Highest ROE Stocks Highest FCF Yield Stocks Lowest P/E Ratio Stocks

Figures are sourced from reported fundamentals and the latest end-of-day price. This comparison is informational only and is not investment advice. Past performance does not predict future results. See our methodology. Compiled by TGMCharts Research · data verified October 6, 2026.