Which has grown faster, ACAD or DNLI?

Over the past five years, DNLI grew revenue faster — ACAD at a 19.70% CAGR versus DNLI at 20.68%.

Is ACAD or DNLI more profitable?

ACAD runs the higher net margin — ACAD at 33.42% versus DNLI at -14191.20%.

How have ACAD and DNLI total returns compared?

Over the past 5 years, ACAD delivered 3.52% and DNLI delivered -16.91% annualized total return. Past performance doesn't predict future results.

Acadia Pharmaceuticals Inc. (ACAD) vs Denali Therapeutics Inc. (DNLI)

A side-by-side comparison of Acadia Pharmaceuticals Inc. and Denali Therapeutics Inc. across valuation, profitability, dividends, and growth — built entirely from reported fundamentals, as of October 6, 2026. Differences are shown without an overall score or investment verdict.

ACAD

Acadia Pharmaceuticals Inc.

$3.38B

$19.74HealthcareDelayed quote: Oct 6, 2026, 4:00 PM EDT

DNLI

Denali Therapeutics Inc.

$3.06B

$19.28HealthcareDelayed quote: Oct 6, 2026, 4:00 PM EDT

Total return — ACAD vs DNLI

growth of $100 · dividends reinvested · last 9y

ACAD -34.0% (-4.5%/yr)DNLI -7.2% (-0.8%/yr)DNLI compounded faster over this window

ACAD DNLI

ACAD vs DNLI: by the numbers

•ACAD is the larger company ($3.38B vs $3.06B market cap).
•ACAD is profitable (33.42% net margin) while DNLI runs a net loss (-14191.20%).
•DNLI grew revenue faster over the past five years (20.68% vs 19.70% CAGR).

Metrics side by side

Valuation

Metric	ACAD	DNLI
P/E ratio	8.89	N/A
Forward P/E	32.05	N/A
P/S ratio	2.97	849.04
P/B ratio	2.59	3.66
EV / EBITDA	31.19	N/A
FCF yield	5.16%	N/A

Profitability

Metric	ACAD	DNLI
Gross margin	91.13%	0.00%
Operating margin	7.59%	0.00%
Net margin	33.42%	-14191.20%
ROE	29.12%	-61.24%
ROIC	6.25%	-50.82%

Growth (annualized)

Metric	ACAD	DNLI
Revenue CAGR (5Y)	19.70%	20.68%
Total return CAGR (5Y)	3.52%	-16.91%

Frequently asked

Which has grown faster, ACAD or DNLI?: Over the past five years, DNLI grew revenue faster — ACAD at a 19.70% CAGR versus DNLI at 20.68%.
Is ACAD or DNLI more profitable?: ACAD runs the higher net margin — ACAD at 33.42% versus DNLI at -14191.20%.
How have ACAD and DNLI total returns compared?: Over the past 5 years, ACAD delivered 3.52% and DNLI delivered -16.91% annualized total return. Past performance doesn't predict future results.

Go deeper

Full ACAD analysis Full DNLI analysis Interactive comparison tool

Dig into the metrics

Acadia Pharmaceuticals P/E ratio Acadia Pharmaceuticals ROE Denali Therapeutics ROE Acadia Pharmaceuticals operating margin Denali Therapeutics operating margin Acadia Pharmaceuticals revenue growth Denali Therapeutics revenue growth Acadia Pharmaceuticals free cash flow Denali Therapeutics free cash flow

Acadia Pharmaceuticals & Denali Therapeutics appear in these rankings

Fastest Revenue Growth Stocks Highest ROE Stocks Highest FCF Yield Stocks Lowest P/E Ratio Stocks

Figures are sourced from reported fundamentals and the latest end-of-day price. This comparison is informational only and is not investment advice. Past performance does not predict future results. See our methodology. Compiled by TGMCharts Research · data verified October 6, 2026.