Acadia Pharmaceuticals Inc. (ACAD) vs Amylyx Pharmaceuticals, Inc. (AMLX)

A side-by-side comparison of Acadia Pharmaceuticals Inc. and Amylyx Pharmaceuticals, Inc. across valuation, profitability, dividends, and growth — built entirely from reported fundamentals, as of October 6, 2026. Differences are shown without an overall score or investment verdict.

Compare
Acadia Pharmaceuticals Inc. logo
ACAD
Acadia Pharmaceuticals Inc.
$3.38B
$19.74HealthcareDelayed quote: Oct 6, 2026, 4:00 PM EDT
Amylyx Pharmaceuticals, Inc. logo
AMLX
Amylyx Pharmaceuticals, Inc.
$3.12B
$28.04HealthcareDelayed quote: Oct 6, 2026, 4:00 PM EDT

Total return — ACAD vs AMLX

growth of $100 · dividends reinvested · last 5y
ACAD -14.0% (-3.0%/yr)AMLX +53.7% (+9.0%/yr)AMLX compounded faster over this window
050100150200Start $1002023202420252026$86$154
ACAD AMLX

ACAD vs AMLX: by the numbers

  • •ACAD is the larger company ($3.38B vs $3.12B market cap).
  • •ACAD is profitable (33.42% net margin) while AMLX runs a net loss (0.00%).

Metrics side by side

Valuation

MetricACADAMLX
P/E ratio8.89N/A
Forward P/E32.05N/A
P/S ratio2.97N/A
P/B ratio2.5913.04
EV / EBITDA31.19N/A
FCF yield5.16%N/A

Profitability

MetricACADAMLX
Gross margin91.13%0.00%
Operating margin7.59%0.00%
Net margin33.42%0.00%
ROE29.12%-63.59%
ROIC6.25%-66.60%

Growth (annualized)

MetricACADAMLX
Revenue CAGR (5Y)19.70%N/A
Total return CAGR (5Y)3.52%N/A

Frequently asked

Is ACAD or AMLX more profitable?
ACAD runs the higher net margin — ACAD at 33.42% versus AMLX at 0.00%.

Go deeper

Full ACAD analysisFull AMLX analysisInteractive comparison tool

Dig into the metrics

Acadia Pharmaceuticals P/E ratioAcadia Pharmaceuticals ROEAmylyx Pharmaceuticals ROEAcadia Pharmaceuticals operating marginAmylyx Pharmaceuticals operating marginAcadia Pharmaceuticals revenue growthAmylyx Pharmaceuticals revenue growthAcadia Pharmaceuticals free cash flowAmylyx Pharmaceuticals free cash flow

Acadia Pharmaceuticals & Amylyx Pharmaceuticals appear in these rankings

Fastest Revenue Growth StocksHighest ROE StocksHighest FCF Yield StocksLowest P/E Ratio Stocks

Figures are sourced from reported fundamentals and the latest end-of-day price. This comparison is informational only and is not investment advice. Past performance does not predict future results. See our methodology. Compiled by TGMCharts Research · data verified October 6, 2026.