Align Technology, Inc. (ALGN) vs 23andMe Holding Co. (ME)
ALGN leads on 7 of 9 compared metrics.
A side-by-side comparison of Align Technology, Inc. and 23andMe Holding Co. across valuation, profitability, dividends, and growth — built entirely from reported fundamentals, as of June 14, 2026. The ● marks the stronger figure on each row (cheaper multiple, higher margin/return).
Total return — ALGN vs ME
growth of $100 · last 5yALGN -63.0%ME -99.7%ALGN compounded faster
Log scale — wide-divergence pair
ALGN ME
ALGN vs ME: by the numbers
- •ALGN is the larger company ($12.52B vs $15M market cap).
- •ALGN is profitable (10.50% net margin) while ME runs a net loss (-134.54%).
- •ALGN grew revenue faster over the past five years (7.78% vs -9.07% CAGR).
Which is better, ALGN or ME?
Metric tally: ALGN 7 · ME 2It depends on what you're optimizing for:
GrowthALGN(faster 5Y revenue CAGR)
QualityALGN(higher ROIC)
Metrics side by side
Valuation
| Metric | ALGN | ME |
|---|---|---|
| P/E ratio | 29.34 | — |
| Forward P/E | 15.37 | — |
| P/S ratio | 3.06 | 0.10● |
| P/B ratio | 3.02 | 0.51● |
| PEG ratio | 51.80 | — |
| EV / EBITDA | 13.57 | — |
| FCF yield | 5.48% | — |
Profitability
| Metric | ALGN | ME |
|---|---|---|
| Gross margin | 67.68%● | 53.33% |
| Operating margin | 14.44%● | -114.00% |
| Net margin | 10.50%● | -134.54% |
| ROE | 10.36%● | -721.75% |
| ROIC | 9.94%● | -553.10% |
Growth (annualized)
| Metric | ALGN | ME |
|---|---|---|
| Revenue CAGR (5Y) | 7.78%● | -9.07% |
| EPS CAGR (5Y) | -24.16% | — |
| FCF CAGR (5Y) | -1.16% | — |
| Total return CAGR (5Y) | -22.14%● | -68.93% |
Frequently asked
- Which is better, ALGN or ME?
- It depends on your goal. growth: ALGN (faster 5Y revenue CAGR); quality: ALGN (higher ROIC). Across all compared metrics, ALGN leads 7 to 2.
- Which has grown faster, ALGN or ME?
- Over the past five years, ALGN grew revenue faster — ALGN at a 7.78% CAGR versus ME at -9.07%.
- Is ALGN or ME more profitable?
- ALGN runs the higher net margin — ALGN at 10.50% versus ME at -134.54%.
- Which has been the better investment, ALGN or ME?
- Over the past 5-year, ALGN delivered the higher annualized total return — ALGN at 8.29% versus ME at -68.93%. Past performance doesn't predict future results.
Go deeper
Dig into the metrics
Align Technology P/E ratio23andMe P/E ratioAlign Technology dividend yield23andMe dividend yieldAlign Technology ROE23andMe ROEAlign Technology operating margin23andMe operating marginAlign Technology revenue growth23andMe revenue growthAlign Technology free cash flow23andMe free cash flow
Align Technology & 23andMe appear in these rankings
Figures are sourced from reported fundamentals and the latest end-of-day price. This comparison is informational only and is not investment advice. Past performance does not predict future results. See our methodology. Compiled by TGMCharts Research · data verified June 14, 2026.